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Anti-RNA polymerase II CTD repeat YSPTSPS Antibody (CTD 4H8)

Monoclonal antibody to detect RNA polII
Catalog #: A1289

Product Details

Cat # +Size A1289-100
Size 100 µg
Antibody Target POLR2A
Alternate Name RNA Polymerase II; Anti-RNA polymerase II CTD repeat YSPTSPS Antibody (CTD 4H8)
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen 10 repeats of synthetic peptide YSPTSPS using chemically synthesized phospho-Ser5
Gene ID 5430
Appearance Colorless liquid
Species Reactivity Human, Yeast
Application ChIP, ELISA, FACS, IHC, IF, IP, ChIP-seq, WB
Positive Control WB: HeLa cell lysate
Application & Usage ChIP, ELISA, FACS, IHC, IF, IP, ChIP-seq WB: 1:1000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


RNAPII is an essential component of the RNAP II transcription elongation complex. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the C-terminal repeat (YSPTSPS) domain of the largest subunit of RNAPII. Mutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation.

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