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Anti-Pyruvate Dehydrogenase E2 Polyclonal Antibody

Part of the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl CoA
Catalog #: A2336
SKU-Size Size Price Qty
A2336-50 50 µl
$165.00
A2336-100 100 µl
$265.00
More Sizes Get Quote

Product Details

Antibody Target Human pyruvate dehydrogenase E2
Alternate Name Dihydrolipoamide S-Acetyltransferase; PDC-E2; PDCE2; DLTA; PBC; E2; DLAT
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant fusion protein of human pyruvate dehydrogenase E2
Accession # P10515
Gene ID 1737
Appearance Liquid
Formulation In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purification
Species Reactivity Mouse, Rat, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The multi-component pyruvate dehydrogenase complex is a group of enzymes in the inner mitochondrial membrane that catalyzes the conversion of pyruvate into acetyl coenzyme A and links glycolysis to the Krebs cycle in cellular respiration. The E2 component, also known as dihydrolipoamide acetyltransferase, accepts the acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to conezyme A. The E2 component is an antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis. Disruptions in the E2 gene can cause a deficiency in E2 protein, which can in turn cause primary lactic acidosis in infancy and early childhood.


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