Product Details
| Size | 100 µl |
|---|---|
| Antibody Target | Pyruvate Carboxylase |
| Alternate Name | Pyruvate carboxylase mitochondrial; Pyruvic carboxylase; PCB |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH-conjugated synthetic peptide targeting a sequence within the center region of human Pyruvate Carboxylase. |
| Accession # | P11498 |
| Gene ID | 5091 |
| Appearance | Colorless liquid |
| Formulation | In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide |
| Purification | Affinity purified |
| Species Reactivity | Zebrafish, Sheep, Bovine, Porcine, Monkey, Mouse, Rat, Chicken, Human |
| Application | Western Blotting |
| Application & Usage | WB 1:500 - 1:1000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyze the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
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