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Anti-Pyruvate Carboxylase Antibody

Affinity purified rabbit polyclonal antibody to detect Pyruvate Carboxylase expression in human, mouse, rat bovine, chicken, monkey, porcine, sheep and zebrafish samples
Catalog #: A2020
$325.00

Product Details

Size 100 µl
Antibody Target Pyruvate Carboxylase
Alternate Name Pyruvate carboxylase mitochondrial; Pyruvic carboxylase; PCB
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the center region of human Pyruvate Carboxylase.
Accession # P11498
Gene ID 5091
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Zebrafish, Sheep, Bovine, Porcine, Monkey, Mouse, Rat, Chicken, Human
Application Western Blotting
Application & Usage WB 1:500 - 1:1000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyze the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.


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