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Anti-PUM2 Antibody

Polyclonal antibody to detect endogenous levels of PUM2 in human, mouse and rat sample
Catalog #: A1690

In stock

$395.00

Product Details

Cat # +Size A1690-100
Size 100 µl
Antibody Target PUM2
Alternate Name PUMH2; Pumilio (Drosphila) homolog 2; Pumilio homolog 2 (Drosophila); Pumilio homolog 2; Pumilio-2; Pumilio2; PUML2;
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen A synthesized peptide derived from human PUM2
Accession # Q8TB72
Gene ID 23369
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purification
Species Reactivity Rat,Mouse,Human
Application Western Blotting,ELISA
Application & Usage WB 1:1000-3000,ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level.


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