Product Details
| Cat # +Size | A2229-100 |
|---|---|
| Size | 100 μl |
| Antibody Target | PON1 |
| Alternate Name | Paraoxonase 1, PON 1, K-45, ESA, PON, EC 3.1.1.81, EC 3.1.1.2, EC 3.1.8.1, MVCD5, PON1 |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide derived from human PON1 |
| Accession # | P27169 |
| Gene ID | 5444 |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Purification | Affinity purified |
| Species Reactivity | Rat, Mouse, Human |
| Application | Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting |
| Application & Usage | WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200 |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high-density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
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