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Anti-PLAP (Placental alkaline phosphatase) Rabbit Monoclonal Antibody (RM317)

affinity purified Rabbit monoclonal to PLAP
Catalog #: A1836
$240.00

Product Details

Cat # +Size A1836-50
Size 50 µl
Antibody Target PLAP (Placental alkaline phosphatase)
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the N-terminus of human PLAP (Placental alkaline phosphatase)
Accession # P05187
Gene ID 250
Appearance Liquid
Formulation 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Protein A affinity purified from an animal origin–free culture supernatant
Species Reactivity Human
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage IHC: 1:500-1:1000, Western Blot: 1:1000-1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Alkaline Phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins, and alkaloids. In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta. The optimal pH for the enzyme activity is pH 10 in standard conditions. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.


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