Product Details
| Cat # +Size | A1132-50 |
|---|---|
| Size | 50 µl |
| Antibody Target | RPS6KA1 |
| Alternate Name | rsk-1, rsk 1, Active RSK1, RSK1, RSK, human RSK1, active kinase, active kinases, recombinant RSK1, recombinant RSK, kinase activity assay, protein kinase |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Isotype | Rabbit IgG |
| Immunogen | A phospho-peptide corresponding to human phospho-Rsk1 (Thr359/Ser363) |
| Accession # | Q15418 , Q15349 |
| Gene ID | 6195 , 6196 |
| Appearance | Colorless liquid |
| Formulation | In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Purification | Affinity purified using protein A |
| Species Reactivity | Human |
| Application | IHC, WB |
| Positive Control | WB: A431 cell lysate; IHC: human cerebral cortex tissue |
| Application & Usage | WB: 1:1000 - 1:2000 dilution; IHC: 1:200 -1:500 dilution |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk). RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. Moller described the cloning and characterization of 3 genes encoding RSKs, and HU1 (also named RPS6KA1, or RSK1) cDNA encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. Northern blot and RNase protection analyses detected an approximately 3.5-kb HU1 transcript in lymphocytes, skeletal muscle, liver, and adipose tissue. Zeniou determined the expression of the RSK1, RSK2, and RSK3 genes in various human tissues, during mouse embryogenesis, and in mouse brain. RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation.
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