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Anti-Phospho-ERK1/2 (Thr202/Tyr204) Antibody

Polyclonal antibody to detect endogenous levels of ERK1/2 (pThr202/Tyr204) in human, mouse and rat samples
Catalog #: A1589
$395.00

Product Details

Cat # +Size A1589-100
Size 100 µg
Antibody Target Mitogen-activated protein kinase 3
Alternate Name Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERK-1, Extracellular signal-regulated kinase 1, ERK-1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human ERK1/2 around the phosphorylation site of Threonine 202/Tyrosine 204
Accession # P27361
Gene ID 5595
Appearance Colorless liquid
Formulation In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Positive Control WB: HeLa cell lysate, IHC: human small instestinal carcinoma, IF: lovo cells
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50- 1:200, IF; 1-200
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.


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