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Anti-PD-L1 Monoclonal Antibody (Clone: ABM5F25)

Monoclonal antibody for the detection of PD-L1 in human cells and tissues
Catalog #: A1537

In stock

$235.00

Product Details

Cat # +Size A1537-50
Size 50 µg
Antibody Target PD-L1
Alternate Name CD274,B7H1,PDCD1L1,PDCD1LG1,PDL1
Host Mouse
Antibody Type Monoclonal
Isotype IgG2b Kappa
Immunogen A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen
Accession # Q9NZQ7
Gene ID 29126
Appearance Colorless Liquid
Formulation 0.5mg/ml in Supplied in PBS containing 0.05% BSA and 0.05% Sodium azide.
Purification Protein G Chromatography
Species Reactivity Human
Application WB, FACS, IHC
Application & Usage WB: 2-4 mg/ml; FACS: 0.5-1mg/106 cells; IHC: 5-10mg/ml
Handling The antibody solution should be gently mixed before use
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.


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