Product Details
| Cat # +Size | A2109-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | PD-L1 |
| Alternate Name | PDL1, PD-L1, PD L1, B7-H, B7H1, B7-H1, CD274, PDCD1L1, B7 homolog 1, PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1 |
| Host | CHO cells |
| Antibody Type | Monoclonal |
| Isotype | Human IgG1, kappa |
| Immunogen | Human PD-L1 |
| Accession # | DB11714 |
| Appearance | Colorless liquid |
| Formulation | In PBS buffer, pH 7.2 |
| Application | HTRF assay |
| Application & Usage | HTRF assay |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | 4°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The research-grade biosimilar is a human IgG1 monoclonal antibody that is produced by
recombinant DNA technology in CHO cells to target programmed cell death-ligand 1 (PD-L1). PD-L1 is an immune inhibitory receptor
ligand that is expressed by T and B lymphocytes, as well as various types of tumor cells to escape immune surveillance. Binding of PDL1
to the PD-1 and B7.1 receptors occurs on T cells and antigen-presenting cells that results in suppression of cytotoxic T-cell activity,
T-cell proliferation, and cytokine production. During infection or inflammation, PD-L1 plays a role in preventing autoimmunity by
maintaining homeostasis of the immune response.
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