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Anti-PD-L1 (Avelumab), Human IgG1 Antibody

The biosimilar antibody is a human monoclonal antibody that binds to PD-L1 and inhibits the interaction with PD-1 and promotes anti-tumor immune response. The original drug received approval from the FDA to treat Merkel cell carcinoma and is currently been investigated in clinical trials for multiple cancers
Catalog #: A2152
$455.00

Product Details

Cat # +Size A2152-100
Size 100 μg
Antibody Target PD-L1
Alternate Name MSB-0010718C, MSB0010682, B7-H, B7H1, B7-H1, CD274, PDCD1L1, PDL1, PD-L1, B7 homolog 1, PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, lambda
Immunogen Human PD-L1
Accession # DB11945
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a human IgG1 lambda monoclonal antibody that specifically targets programmed death-ligand 1 (PD-L1). Binding of PD-L1 to the PD-1 and B7.1 receptors occurs on T cells and antigen-presenting cells that results in suppression of cytotoxic T-cell activity, T-cell proliferation, and cytokine production. The antibody binds PD-L1 through the FG loops and blocks the interaction between PD-L1 and its receptors PD-1 and B7.1. This releases the suppression of immune responses and promotes the inhibition of tumor growth. Studies show that the drug is capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro. The original drug received FDA approval to treat Merkel cell cancer. It is currently been used in immunotherapy for several cancers


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