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Anti-PD-L1 Antibody

Polyclonal Antibody to detect PD-L1 in human samples
Catalog #: A1454

In stock

SKU-Size Size Price Qty
A1454-30T 30 µg
$89.00
A1454-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target PD-L1
Alternate Name PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant human PD-L1
Accession # Q9NZQ7
Gene ID 29126
Appearance Colorless liquid
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
Purification Affinity purified
Species Reactivity Human
Application WB
Positive Control WB: PD-L1 human recombinant
Application & Usage WB: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Programmed death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.


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