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Anti-PD-L1 Antibody (IHC411)

Monoclonal Antibody to detect PD-L1 in human samples
Catalog #: A1549

In stock

$125.00

Product Details

Cat # +Size A1549-50
Size 50 µl
Antibody Target PD-L1
Alternate Name Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, programmed death ligand 1, B7 homolog 1, B7-H1, CD274
Host Rabbit
Antibody Type Monoclonal
Immunogen PD-L1
Accession # Q9NZQ7
Gene ID 29126
Appearance Colorless liquid
Formulation Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Purification Protein A/G purification
Species Reactivity Human
Application IHC
Positive Control IHC: Lung
Application & Usage IHC: 1:100 - 1:200
Handling The antibody solution should be gently mixed before use
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.


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