Product Details
| Cat # +Size | A1549-50 |
|---|---|
| Size | 50 µl |
| Antibody Target | PD-L1 |
| Alternate Name | Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, programmed death ligand 1, B7 homolog 1, B7-H1, CD274 |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Immunogen | PD-L1 |
| Accession # | Q9NZQ7 |
| Gene ID | 29126 |
| Appearance | Colorless liquid |
| Formulation | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human |
| Application | IHC |
| Positive Control | IHC: Lung |
| Application & Usage | IHC: 1:100 - 1:200 |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | 4°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.
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