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Anti-PD-1, Humanized Antibody (Tp2)

Biosimilar to Toripalimab, monoclonal antibody that targets PD-1
Catalog #: A2161
$455.00

Product Details

Cat # +Size A2161-100
Size 100 μg
Antibody Target PD-1
Alternate Name PD1, PDCD1, CD279, SLEB2, hPD-1, hPD-l, hSLE1
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human PD-1
Accession # DB15043
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized IgG4 recombinant monoclonal antibody that binds to programmed death receptor-1 (PD-1). PD-1 is an important immune checkpoint protein expressed on activated T-cells, B-cells, and macrophages. PD-1 is involved in the regulation of T cell functions, including those of effector CD8-positive T cells. PD-1 can also promote the differentiation of CD4-positive T cells into T regulatory cells, and is involved in safeguarding against autoimmunity. Binding of PD-1 to its ligands PD-L1 and PD-L2 prevent T-cell activation and cytokine production. PD-1 is expressed in many types of tumors including melanomas, and has been shown to play a role in anti-tumor immunity.


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