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Anti-PD-1 (Sintilimab), Human IgG4 Antibody

The biosimilar is a human monoclonal antibody that targets PD-1, inhibits PD-1 mediated signaling, and restores immune responses against tumor cells. The original drug is approved for the treatment of Hodgkin’s lymphoma and is currently in clinical trials to treat various cancers
Catalog #: A2156
$455.00

Product Details

Cat # +Size A2156-100
Size 100 μg
Antibody Target PD-1
Alternate Name IBI-308, PDCD1, PD1, CD279
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG4, kappa
Immunogen Human PD-1
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets the human cell surface receptor programmed cell death-1 (PD-1), an immune checkpoint protein with neoplastic functions. The antibody binds to PD-1 and prevents the association with its ligands PD-L1 and PD-L2. This results in inhibition of PD-1 and its downstream signaling, leading to the activation of T-cells and T-cell mediated immune response to inhibit tumor growth. The original drug is approved in China to treat relapsed or refractory patients with classic Hodgkin’s lymphoma, after the second-line of chemotherapy. Currently, this drug is in the process of FDA approval for use in the United States. The drug is undergoing clinical trials to test for safety and efficacy in the treatment of cancers such as non-small cell lung cancer and esophageal cancer


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