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Anti-PCSK9 (Evolocumab), Human IgG2 Antibody

The biosimilar is a human monoclonal antibody that targets PCSK9 and inhibits the binding with LDL receptors on the hepatocyte cell surface and promotes the clearance of LDL-C from the blood
Catalog #: A2168
$455.00

Product Details

Cat # +Size A2168-100
Size 100 μg
Antibody Target PCSK9
Alternate Name AMG-145, AMG145, NN7415, FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC-1, HCHOLA3
Host Recombinant
Antibody Type Monoclonal
Isotype IgG2, lambda
Immunogen Human PCSK9
Accession # DB09303
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a human IgG2 monoclonal antibody that is directed against proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a serine protease that binds to LDL receptors on the hepatocyte cell surface and promotes the lysosome-mediated degradation of these receptors. This results in decreased uptake and clearance of LDL-C (bad cholesterol) by the receptors. The monoclonal antibody binds to PCSK9 and prevents interaction with the LDL receptor. This promotes the recycling of the internalized LDL receptor to the hepatocyte cell surface and increased removal of LDL-C from the blood. The original drug received approval from the FDA to treat homozygous and heterozygous familial cholesterolemia. The drug has also been approved to treat patients with high cholesterol, whose LDL-C was not controlled by the statin treatment.


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