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Anti-PCSK9 (Alirocumab), Human IgG1 Antibody

The biosimilar is a human monoclonal antibody that binds to free PCSK9 and promotes degradation of this enzyme, thereby facilitating more uptake of LDL-C by the liver and a higher rate of clearance from circulation. The original drug received FDA approval to treat adults with heterozygous familial hypercholesterolemia
Catalog #: A2153
$455.00

Product Details

Cat # +Size A2153-100
Size 100 μg
Antibody Target PCSK9
Alternate Name REGN727, SAR-236553, FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human PCSK9
Accession # DB09302
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar antibody is a fully human IgG1 monoclonal antibody that binds to and inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme that has "gain-of-function" mutations in autosomal dominant hypercholesterolemia. PCSK9 is secreted by the liver and binds to the LDL receptors in serum and marks them for lysosomal degradation. As a result, the LDL receptors are unable to recycle to the plasma membrane, thus reducing their binding to LDL-C and subsequent clearance of LDL-C from plasma. Therefore, by binding to free PCSK9, the biosimilar allows more LDL-C reuptake by the liver and facilitates a higher rate of clearance of LDL-C. The original drug received approval from the FDA as a second-line of treatment for heterozygous familial hypercholesterolemia in adults, whose LDL-C was not controlled by the combination of diet and statin treatment.


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