Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


Anti-PCSK9 (Alirocumab), Human IgG1 Antibody

The biosimilar is a human monoclonal antibody that binds to free PCSK9 and promotes degradation of this enzyme, thereby facilitating more uptake of LDL-C by the liver and a higher rate of clearance from circulation. The original drug received FDA approval to treat adults with heterozygous familial hypercholesterolemia
Catalog #: A2153

Product Details

Cat # +Size A2153-100
Size 100 μg
Antibody Target PCSK9
Alternate Name REGN727, SAR-236553, FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human PCSK9
Accession # DB09302
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar antibody is a fully human IgG1 monoclonal antibody that binds to and inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme that has "gain-of-function" mutations in autosomal dominant hypercholesterolemia. PCSK9 is secreted by the liver and binds to the LDL receptors in serum and marks them for lysosomal degradation. As a result, the LDL receptors are unable to recycle to the plasma membrane, thus reducing their binding to LDL-C and subsequent clearance of LDL-C from plasma. Therefore, by binding to free PCSK9, the biosimilar allows more LDL-C reuptake by the liver and facilitates a higher rate of clearance of LDL-C. The original drug received approval from the FDA as a second-line of treatment for heterozygous familial hypercholesterolemia in adults, whose LDL-C was not controlled by the combination of diet and statin treatment.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.