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Anti-PCSK9, Human IgG1 Antibody (Ac1)

Biosimilar to Alirocumab, monoclonal antibody that targets PCSK9
Catalog #: A2153
$455.00

Product Details

Cat # +Size A2153-100
Size 100 μg
Antibody Target PCSK9
Alternate Name FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human PCSK9
Accession # DB09302
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar antibody is a fully human IgG1 monoclonal antibody that binds to proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme that has "gain-of-function" mutations in autosomal dominant hypercholesterolemia. PCSK9 plays a role in cholesterol and fatty acid metabolism. PCSK9 is secreted by the liver and binds to the LDL receptors in serum and marks them for lysosomal degradation. As a result, the LDL receptors are unable to recycle to the plasma membrane, thus reducing their binding to LDL-C and subsequent clearance of LDL-C from plasma.


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