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Anti-Notch 1 (Cleaved-Val1744) Antibody

Polyclonal antibody to detect endogenous levels of Notch 1 in human samples
Catalog #: A1619

In stock

$395.00

Product Details

Cat # +Size A1619-100
Size 100 µl
Antibody Target Notch 1
Alternate Name AOS5; AOVD1; hN1; Lin-12; LIN12; Mis6; Motch A; mT14; Neurogenic locus notch homolog protein 1; Neurogenic locus notch protein homolog; NICD; NOTC1_HUMAN; Notch 1; Notch 1 intracellular domain; NOTCH; Notch gene homolog 1 (Drosophila); Notch homolog 1, tr
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human Notch 1 (Cleaved-Val1744)
Accession # P46531
Gene ID 4851
Appearance Colorless liquid
Formulation In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Positive Control WB: 3T3 cell extract, IHC: Mouse spleen tissue
Application & Usage WB 1:500-1:2000 , IHC 1:50-1:200 , ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Notch proteins are transmembrane receptor that regluate cell fate decisions. Four Notch homologs have been identified in mammals namely Notch 1, Notch 2, Notch 3 and Notch 4. The membrane ligand for Notch includes Jagged 1, Jagged 2 and Delta. Notch 1 is a 270 kDa transmembrane receptor that can be activated by Delta (Dl) ligand. Activation of Notch 1 will result in the proteolytic cleavage of Notch 1 into a 120 kDa length protein.


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