Product Details
| Cat # +Size | A1619-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | Notch 1 |
| Alternate Name | AOS5; AOVD1; hN1; Lin-12; LIN12; Mis6; Motch A; mT14; Neurogenic locus notch homolog protein 1; Neurogenic locus notch protein homolog; NICD; NOTC1_HUMAN; Notch 1; Notch 1 intracellular domain; NOTCH; Notch gene homolog 1 (Drosophila); Notch homolog 1, tr |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | A synthesized peptide derived from human Notch 1 (Cleaved-Val1744) |
| Accession # | P46531 |
| Gene ID | 4851 |
| Appearance | Colorless liquid |
| Formulation | In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Purification | Affinity purified |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC, ELISA |
| Positive Control | WB: 3T3 cell extract, IHC: Mouse spleen tissue |
| Application & Usage | WB 1:500-1:2000 , IHC 1:50-1:200 , ELISA (peptide) 1:20000-1:40000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Notch proteins are transmembrane receptor that regluate cell fate decisions. Four Notch homologs have been identified in mammals namely Notch 1, Notch 2, Notch 3 and Notch 4. The membrane ligand for Notch includes Jagged 1, Jagged 2 and Delta. Notch 1 is a 270 kDa transmembrane receptor that can be activated by Delta (Dl) ligand. Activation of Notch 1 will result in the proteolytic cleavage of Notch 1 into a 120 kDa length protein.
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