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Product Details
| Cat # +Size | A1591-50 |
|---|---|
| Size | 50 µl |
| Antibody Target | Transcription factor p65 |
| Alternate Name | RELA, NFKB3, MGC131774 |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Isotype | Rabbit IgG |
| Immunogen | A peptide corresponding to the area near the C-terminus of human transcription factor p65 (NFkB p65 subunit) |
| Accession # | Q04206 |
| Gene ID | 5970 |
| Appearance | Colorless liquid |
| Formulation | In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | WB, IHC |
| Positive Control | WB: MCF-7 cell lysates, IHC: human breast cancer tissue |
| Application & Usage | WB: 1:500 - 1:1000, IHC: 1:500 -1:1500 |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
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