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Anti-NFkB p65 Rabbit Monoclonal Antibody

Monoclonal antibody to detect endogenous levels of NF kappaB p65 in human samples
Catalog #: A1591
$285.00

Product Details

Cat # +Size A1591-50
Size 50 µl
Antibody Target Transcription factor p65
Alternate Name RELA, NFKB3, MGC131774
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the area near the C-terminus of human transcription factor p65 (NFkB p65 subunit)
Accession # Q04206
Gene ID 5970
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Affinity purified
Species Reactivity Human
Application WB, IHC
Positive Control WB: MCF-7 cell lysates, IHC: human breast cancer tissue
Application & Usage WB: 1:500 - 1:1000, IHC: 1:500 -1:1500
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.


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