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Anti-NEUROD2 Antibody

Polyclonal antibody to detect endogenous levels of NEUROD2 in human and mouse samples
Catalog #: A1648

In stock

$295.00

Product Details

Cat # +Size A1648-100
Size 100 µl
Antibody Target NEUROD2
Alternate Name BHLHA1; NDRF; Neurogenic differentiation factor 2; NeuroD2; Class A basic helix-loop-helix protein 1; bHLHa1; NeuroD-related factor; NDRF
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NEUROD2
Accession # Q15784
Gene ID 4761
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse
Application WB, IHC, IP
Positive Control WB: Jurkat; mouse brain; rat brain whole cell lysates, IHC: human brain tissue
Application & Usage WB; 1:500 – 1:1000, IHC; 1:100 – 1:200, IP; 1:10 – 1:100
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.


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