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Anti-MSLN (Anetumab), Human IgG1 Antibody

The biosimilar is a human IgG1 antibody that targets Mesothelin (MSLN)
Catalog #: A2272
$465.00

Product Details

Cat # +Size A2272-100
Size 100 μg
Antibody Target MSLN
Alternate Name MPF, SMRP, MSLN, Mesothelin, CAK1, CAK1 Antigen
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, lambda
Immunogen Human MSLN
Accession # DB14809
Gene ID 10232
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant antibody to Anetumab without the drug conjugation. The original antibody-drug conjugate (Anetumab Ravtansine) consists of an anti-mesothelin (MSLN) human IgG1 antibody conjugated to DM4, an anti-tumor chemical derivative of maytansine via a disulfide-containing cleavable sulfo-SPDB linker. Upon interaction and internalization by MSLN expressing tumor cells, the DM4 is detached from the antibody due to proteolytic cleavage. The DM4 then inhibits polymerization of the tubulin and disrupts the microtubule assembly, thereby leading to cell cycle arrest and apoptosis. The original antibody-drug conjugate is used as an investigational agent to treat pancreatic, ovarian cancer, and advanced or recurrent mesothelioma.


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