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Anti-MERS-CoV S1 Mouse IgG1 Antibody

Purified mouse monoclonal antibody to detect MERS Coronavirus Spike protein S1. This antibody does not have crossreactivity with SARS Coronavirus
Catalog #: A2065
$265.00

Product Details

Cat # +Size A2065-100
Size 100 μg
Antibody Target MERS-CoV S1
Host Mouse
Antibody Type Monoclonal
Isotype IgG1
Appearance Colorless liquid
Concentration Concentration is lot dependent
Formulation In 10 mM PBS, pH 7.2, 0.1% sodium azide
Purification Affinity purified using protein A
Species Reactivity Human
Application Immunofluorescence (IF), ELISA
Application & Usage ELISA, IFA
Handling The antibody solution should be gently mixed before use.
Storage Conditions 2-8°C (Short term), -20°C (Long term)
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MERS-CoV belongs to the family of Coronaviridae and is characterized by large positive-sense RNA genome, that is 28 kb in length. One unique feature of MERS-CoV is that two-thirds of the viral genome is translated into two large polyproteins whereas the remaining viral genome is transcribed into sub-genomic RNAs. The two large polyproteins encode multiple non-structural proteins that play an important role in viral replication and transcription. MERS-CoV transcribes multiple sub-genomic RNAs that encode four structural proteins, namely, envelope (E), membrane (M), spike (S), and nucleocapsid (N). The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.


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