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Anti-MEK2 (KO Validated) Antibody

Rabbit monoclonal knockout validated antibody to detect the expression of MEK2 in human and mouse samples
Catalog #: A2124
$340.00

Product Details

Cat # +Size A2124-100
Size 100 µl
Antibody Target MEK2
Alternate Name CFC4; MAPKK2; MEK2; MKK2; PRKMK2; MAP2K2
Host Rabbit
Antibody Type Monoclonal
Isotype IgG
Immunogen Synthetic peptide derived from human MEK2
Accession # P36507
Gene ID 5605
Appearance Colorless liquid
Formulation In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Mouse, Human
Application Western Blotting
Application & Usage WB 1:500 - 1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.


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