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Anti-MASP2 (Narsoplimab), Human IgG4 Antibody

The biosimilar is a human monoclonal antibody that targets and blocks MASP2. This results in inactivation of the lectin pathway and complement-induced thrombus formation
Catalog #: A2203
$455.00

Product Details

Cat # +Size A2203-100
Size 100 μg
Antibody Target MASP2
Alternate Name sMAP, MAP19, MASP-2, MASP1P1, OMS-721, OMS721
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, lambda
Immunogen Human MASP2
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a fully human IgG4 monoclonal antibody that binds to and inhibits mannan-binding lectin associated serine protease 2 (MASP2). MASP2 is a pro-inflammatory protein that plays an important role in the activation of the lectin complement pathway. Additionally, MASP2 has been reported to have factor Xa-like activity and as a result, can cleave prothrombin to thrombin and form fibrin clots. Binding of the antibody to MASP2 prevents the activation of the lectin complement pathway and thrombus formation. The original drug was granted Breakthrough Therapy designation by the FDA to treat hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), immunoglobulin A (IgA) nephropathy and atypical hemolytic uremic syndrome (aHUS). The drug is also under investigation to treat COVID-19 disease.


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