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Anti-MART1 Rabbit Monoclonal Antibody (RM333)

Affinity purified Rabbit monoclonal to MART1
Catalog #: A1845
$240.00

Product Details

Cat # +Size A1845-50
Size 50 µl
Antibody Target MART-1 (Melanoma antigen recognized by T-cells 1)
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the N-terminus of human MART1 (Melanoma antigen recognized by T-cells-1).
Accession # Q16655
Gene ID 2315
Appearance Liquid
Formulation 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Protein A affinity purified from an animal origin–free culture supernatant
Species Reactivity Human
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage Western Blot: 1:500-1:1000, IHC: 1:500-1:1000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is expressed by a large proportion of melanoma tumors, both melanotic and amelanotic and by melanoma cell lines. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Melan-A/MART-1 is not expressed by non-melanoma malignancies. It is recognized by autologous cytotoxic T lymphocytes. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1.


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