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New

Anti-LRH1 Antibody

Polyclonal antibody to detect endogenous levels of LRH1 in human, mouse and rat sample
Catalog #: A1688

In stock

$295.00

Product Details

Cat # +Size A1688-100
Size 100 µl
Antibody Target NR5A2
Alternate Name B1F; CPF; FTF; Nuclear receptor subfamily 5 group A member 2; Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; LRH-1
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant full length protein of human LRH-1
Accession # O00482
Gene ID 2494
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.
Purification Affinity purification
Species Reactivity Rat,Mouse,Human
Application Immunohistochemistry (IHC),Immunofluorescence (IF),Western Blotting
Application & Usage WB 1:500 - 1:2000,F/ICC 1:50 - 1:200,IHC 1:50 - 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.


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