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Anti-KDM5C / Jarid1C / SMCX Antibody (2E4-E1-G8)

Monoclonal antibody to detect KDM5C / Jarid1C / SMCX
Catalog #: A1308

In stock

$295.00

Product Details

Cat # +Size A1308-100
Size 100 µg
Antibody Target KDM5C
Alternate Name MRXJ, SMCX, MRXSJ, XE169, MRXSCJ, JARID1C, DXS1272E, Lysine-specific demethylase 5C, Jumonji/ARID domain-containing protein 1C
Host Human
Antibody Type Monoclonal
Isotype Mouse IgG2a
Immunogen Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli
Accession # P41229
Gene ID 8242
Appearance Colorless liquid
Formulation In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
Purification Affinity purified
Species Reactivity Human
Application WB, IF
Positive Control WB: HeLa, 293, T$7D, MCF7 cell lysates; IF: HeLa cells
Application & Usage WB; 1:1000; IF; 1:150
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2


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