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Anti-JMJD6 Antibody

Polyclonal antibody to detect endogenous levels of JMJD6 in human, mouse and rat sample
Catalog #: A1683

In stock

$295.00

Product Details

Cat # +Size A1683-100
Size 100 µl
Antibody Target JMJD6
Alternate Name KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phospha
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant full length protein of human JMJD6
Accession # 23210
Gene ID 360665
Appearance Liquid
Concentration 1 mg/ml
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.
Purification Affinity purification
Species Reactivity Rat,Mouse,Human
Application Immunohistochemistry (IHC),Western Blotting
Application & Usage IP; 1:50 - 1:200,ChIP; 1:20 - 1:100,WB; 1:500 - 1:2000,IH; 1:50 - 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.


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