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Anti-Irisin Antibody

Polyclonal Antibody to detect Irisin in human, mouse and rat samples
Catalog #: A1459

In stock

SKU-Size Size Price Qty
A1459-30T 30 µg
$89.00
A1459-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Irisin
Alternate Name Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved)
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Human recombinant Irisin
Accession # Q8NAU1
Gene ID 252995
Appearance Colorless liquid
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB
Positive Control WB: Rat kidney lysate, Human recombinant Irisin
Application & Usage WB: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.


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