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Anti-Integrin beta-1 Rabbit Monoclonal Antibody

Monoclonal antibody to detect Integrin beta-1 in human samples.
Catalog #: A1598

In stock

$285.00

Product Details

Cat # +Size A1598-50
Size 50 µl
Antibody Target Integrin beta-1
Alternate Name Integrin beta-1, Fibronectin receptor subunit beta, GPIIA, CD29, FNRB, MDF2, MSK12
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the residues in human CD29 (Integrin beta-1).
Accession # P05556
Gene ID 3688
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Affinity purified
Species Reactivity Human
Application WB, IHC
Positive Control WB: HeLa cell lysate, IHC: human brain tissue, human colon tissue
Application & Usage WB: 1:2000-1:4000, IHC: 1:100-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.


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