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Anti-Integrin β1 Antibody

Polyclonal antibody to detect endogenous levels of Integrin β1 in human, mouse and rat samples
Catalog #: A1669

In stock

$395.00

Product Details

Cat # +Size A1669-100
Size 100 µl
Antibody Target Integrin β1
Alternate Name Integrin beta-1, Fibronectin receptor subunit beta, GPIIA, CD29, FNRB, MDF2, MSK12
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human Integrin β1
Accession # P05556
Gene ID 3688
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, ICC/IF, ELISA
Positive Control WB: Jurkat cells, IF/ICC: HeLa cells
Application & Usage WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.


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