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Anti-IL23α (Risankizumab), Humanized Antibody

The biosimilar is a humanized monoclonal antibody that targets IL-23α and prevents its association with the IL-23 receptor. This results in inhibition of release of pro-inflammatory chemokines and cytokines
Catalog #: A2204
$455.00

Product Details

Cat # +Size A2204-100
Size 100 μg
Antibody Target IL23α
Alternate Name 655066-01, ABBV-066, BI 655066, P19, SGRF, IL-23, IL23A, IL23P19
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human IL23α
Accession # DB14762
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized IgG1 monoclonal antibody that selectively binds to the p19 subunit of IL-23α. IL-23 is a pro-inflammatory cytokine that is primarily secreted by dendritic cells, monocytes, and macrophages. It is a heterodimeric complex that consists of p19 and p40 subunit. p19 subunit is unique for IL-23 whereas the p40 subunit is shared with IL-12. IL-23 plays an important role in the pathogenesis of inflammatory diseases such as psoriasis. Binding of the antibody to IL-23α prevents the interaction with IL-23 receptor and thereby inhibits inflammatory responses. The original drug received approval from the FDA to treat patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy


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