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Anti-IL-6Rα (Sarilumab), Human IgG1 Antibody

A fully human anti-IL-6Rα monoclonal antibody that binds membrane-bound and soluble human IL-6Rα with high affinity
Catalog #: A2133

Product Details

Cat # +Size A2133-100
Size 100 µg
Antibody Target PD-1
Alternate Name IL6Q, gp80, CD126, IL6RA, IL6RQ, IL-6RA, IL-6R-1, HIES5, IL-6R, IL-1Ra, IL6QTL, IL-6R-Alpha, IL6R, IL-6R 1
Host CHO cells
Antibody Type Monoclonal
Isotype Human IgG1
Immunogen Sarilumab
Gene ID 3570
Appearance Colorless liquid
Concentration Lot specific
Formulation In PBS buffer, pH 7.2
Application In vitro and In vivo studies
Application & Usage In vitro and In vivo studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is a fully human anti-IL-6R monoclonal IgG1 antibody that can bind to membrane as well as soluble forms of interleukin 6 receptor (IL-6R). This leads to inhibition of IL-6 mediated signaling and reduced release of CRP, serum amyloid A and fibrinogen, which are potential biomarkers of rheumatoid arthritis (RA). The original monoclonal antibody received US-FDA approval in 2017 to treat moderate to severe RA in combination with methotrexate. The original antibody is currently being evaluated for phase 3 clinical trial on COVID-19 patients

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