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Product Details
| Cat # +Size | A2133-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | PD-1 |
| Alternate Name | IL6Q, gp80, CD126, IL6RA, IL6RQ, IL-6RA, IL-6R-1, HIES5, IL-6R, IL-1Ra, IL6QTL, IL-6R-Alpha, IL6R, IL-6R 1 |
| Host | CHO cells |
| Antibody Type | Monoclonal |
| Isotype | Human IgG1 |
| Immunogen | Sarilumab |
| Gene ID | 3570 |
| Appearance | Colorless liquid |
| Concentration | Lot specific |
| Formulation | In PBS buffer, pH 7.2 |
| Application | In vitro and In vivo studies |
| Application & Usage | In vitro and In vivo studies |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | 4°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The research-grade biosimilar is a fully human anti-IL-6R monoclonal IgG1 antibody that can bind to membrane as well as soluble forms of interleukin 6 receptor (IL-6R). This leads to inhibition of IL-6 mediated signaling and reduced release of CRP, serum amyloid A and fibrinogen, which are potential biomarkers of rheumatoid arthritis (RA). The original monoclonal antibody received US-FDA approval in 2017 to treat moderate to severe RA in combination with methotrexate. The original antibody is currently being evaluated for phase 3 clinical trial on COVID-19 patients
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