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Anti-IL-4Rα (Dupilumab), Human IgG4 Antibody

The biosimilar is a fully human monoclonal antibody that binds to IL-4 receptor and inhibits IL-4 receptor-mediated signaling of pro-inflammatory cytokines that play a central role in inflammatory and allergic conditions. This monoclonal antibody received FDA approval for the treatment of eczema, moderate to severe asthma, and chronic rhinosinusitis.
Catalog #: A2148
$455.00

Product Details

Cat # +Size A2148-100
Size 100 μg
Antibody Target IL-4Rα
Alternate Name CD124, REGN668, REGN 668, REGN-668, SAR231893, SAR 231893, SAR-231893
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human IL-4Rα
Accession # DB12159
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Application In vitro studies
Application & Usage In vitro studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets IL-4Rα and inhibits IL-4 and IL-13 signaling, which play an important role in Th-2 mediated immune response and thus downregulates Type 2 inflammation. The biosimilar was generated in CHO cells using recombinant DNA technology. The original drug was developed by Sanofi and Regeneron and received approval from the FDA for the treatment of atopic dermatitis and eczema. Additionally, this drug received approval to treat patients aged 12 years and above, suffering from moderate-to-severe asthma, and moderate-to-severe eosinophilic asthma or oral corticosteroid-dependent asthma.


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