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Anti-IL-17Rα (Brodalumab), Human IgG2 Antibody

The biosimilar is a human monoclonal antibody that targets IL-17Rα and inhibits the release of pro-inflammatory cytokines and chemokines. The original drug is approved by the FDA to treat plaque psoriasis
Catalog #: A2155
$455.00

Product Details

Cat # +Size A2155-100
Size 100 μg
Antibody Target IL-17Rα
Alternate Name AMG827, KHK4827, AMG 827, AMG-827, KHK-4827, KHK4827, IL17RA, CD217
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG2, kappa
Immunogen Human IL-17Rα
Accession # DB11776
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant, fully human IgG2 kappa monoclonal antibody that binds with a high affinity to the Interleukin-17 receptor α (IL-17Rα). IL-17R is a type I membrane glycoprotein that is ubiquitously expressed on cell surfaces and binds IL17α with low affinity. IL17α plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis. The antibody binds to the IL-17Rα and inhibits IL-17 induced release of pro-inflammatory cytokines and chemokines such as NF-κB, IL-6, IL-8, COX-2, MMPs, and GM-CSF. The original drug received approval from the FDA to treat moderate-to-severe psoriasis


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