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Anti-IL-17α (Secukinumab), Human IgG1 Antibody

The biosimilar antibody is a human monoclonal that selectively targets IL-17α, a pro-inflammatory cytokine that is highly expressed during inflammatory conditions and immune responses. The original drug received FDA approval to treat adults with moderate-to-severe plaque psoriasis, ankylosing spondylitis, and psoriasis
Catalog #: A2154
$455.00

Product Details

Cat # +Size A2154-100
Size 100 μg
Antibody Target IL-17α
Alternate Name AIN-457, AIN457, AIN457A, IL17, CTLA8, IL-17, CTLA-8, IL17A
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human IL-17α
Accession # DB09029
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Application In vitro studies
Application & Usage In vitro studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Secukinumab is a human IgG1 monoclonal antibody that targets IL-17α and prevents its association with the receptor IL-17R. This results in decreased release of proinflammatory cytokines and chemokines and downregulation of inflammation. IL-17 represents a family of cytokines (IL-17 A-F), that is released by T-helper-17 (Th17) cells, mast cells, neutrophils, and dendritic cells and promotes inflammation. Studies show that IL-17 is associated with multiple autoimmune diseases such as rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn's disease, and multiple sclerosis. The original drug received approval from the FDA to treat plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis.


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