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Anti-IL-17α (Ixekizumab), Humanized Antibody

The biosimilar is a humanized monoclonal antibody used for the treatment of autoimmune diseases. The antibody specifically targets IL-17α and inhibits IL-17α mediated inflammatory responses. The original drug is approved by the FDA to treat psoriasis and psoriatic arthritis
Catalog #: A2149
$455.00

Product Details

Cat # +Size A2149-100
Size 100 μg
Antibody Target IL-17α
Alternate Name LY 2439821, LY-2439821, LY2439821, IL17a, IL17, CTLA8, IL-17, CTLA-8, IL-17A
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human IL-17α
Accession # DB11569
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized IgG4 monoclonal antibody that targets IL-17α and prevents the interaction with its receptor (IL-17R), thus blocking IL-17α mediated inflammatory and immune responses. IL-17α is known to play an important role in autoimmune diseases such as rheumatoid arthritis and plaque psoriasis. The monoclonal antibody is produced in CHO cells using recombinant DNA technology. It consists of two identical light chains of 219 amino acids each and two identical heavy chains of 445 amino acids each. The original drug was developed by Eli Lily and received approval from the FDA for the treatment of adults suffering from moderate-to-severe psoriasis and psoriatic arthritis


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