Product Details
| Cat # +Size | A1413-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | IL-16 |
| Alternate Name | Pro-interleukin-16 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IL-16 |
| Accession # | Q14005 |
| Gene ID | 3603 |
| Appearance | Colorless liquid |
| Formulation | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | WB |
| Positive Control | WB: human blood (A); Jurkat (B) whole cell lysates. |
| Application & Usage | WB; 1:500 – 1:2000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
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