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Anti-IL-1β (Canakinumab), Human IgG1 Antibody

A human monoclonal antibody that targets and neutralizes IL-1β and prevents IL-1 mediated autoinflammatory disorders
Catalog #: A2144

Product Details

Cat # +Size A2144-100
Size 100 μg
Antibody Target IL-1β
Alternate Name IL-1, IL1F2, IL1beta, IL1-BETA, IL1B
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human IL-1β
Accession # DB06168
Appearance Colorless liquid
Concentration Lot specific
Formulation In PBS pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is a recombinant human IgG1 kappa monoclonal antibody that is produced in murine Sp2/0-Ag14 cell line. This antibody binds to and neutralizes human IL-1β preventing association with its receptor and subsequent inflammatory signaling cascade. The antibody neither has cross-reactivity with IL-1α nor with the Interleukin 1 receptor, type I (IL1R1). The original monoclonal antibody was developed to treat rheumatoid arthritis. It received FDA approval in 2009 to treat cryopyrin-associated periodic syndromes (CAPS). Additionally, in 2016, the original antibody also received approval for the treatment of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulinemia D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD), and Familial Mediterranean Fever (FMF).

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