Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Anti-IL-1β (Canakinumab), Human IgG1 Antibody

A human monoclonal antibody that targets and neutralizes IL-1β and prevents IL-1 mediated autoinflammatory disorders
Catalog #: A2144
$415.00

Product Details

Cat # +Size A2144-100
Size 100 μg
Antibody Target IL-1β
Alternate Name IL-1, IL1F2, IL1beta, IL1-BETA, IL1B
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human IL-1β
Accession # DB06168
Appearance Colorless liquid
Concentration Lot specific
Formulation In PBS pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant human IgG1 kappa monoclonal antibody that is produced in murine Sp2/0-Ag14 cell line. This antibody binds to and neutralizes human IL-1β preventing association with its receptor and subsequent inflammatory signaling cascade. The antibody neither has cross-reactivity with IL-1α nor with the Interleukin 1 receptor, type I (IL1R1). The original monoclonal antibody was developed to treat rheumatoid arthritis. It received FDA approval in 2009 to treat cryopyrin-associated periodic syndromes (CAPS). Additionally, in 2016, the original antibody also received approval for the treatment of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulinemia D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD), and Familial Mediterranean Fever (FMF).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.