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Anti-IFN-γ (Emapalumab), Human IgG1 Antibody

The biosimilar is a human IgG1 monoclonal antibody targeting Interferon-gamma (IFN-γ)
Catalog #: A2270
$460.00

Product Details

Cat # +Size A2270-100
Size 100 μg
Antibody Target Interferon gamma (IFN-γ)
Alternate Name IFG, IFI, IMD69, IFNG, Interferon Gamma, Immune Interferon, IFN-Gamma
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, lambda
Immunogen Human IFN-γ
Accession # DB14724
Gene ID 3458
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant human IgG1 monoclonal antibody that targets interferon-gamma (IFN-γ). Interferon-gamma is a cytokine secreted by immune cells such as natural killer (NK), natural killer T (NKT) cells, and cytotoxic T-lymphocyte cells in response to pathogen attack. It can directly inhibit viral replication and also stimulate and regulate inflammation. Increased inflammation or autoimmune diseases such as arthritis, lupus, and primary hemophagocytic lymphohistiocytosis (HLH) cause abnormally high levels of interferon-gamma. The original monoclonal antibody non-competitively binds to interferon-gamma and prevents its association with interferon receptors located on the cell surface, and ultimately causing inactivation of pro-inflammatory signaling pathways. The original monoclonal antibody received FDA approval to treat adult and pediatric patients suffering from primary hemophagocytic lymphohistiocytosis (HLH) and intolerant to HLH therapy.


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