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Anti-HMGB1Monoclonal Antibody (Clone: ABM2E44)

Monoclonal antibody for the detection of HMGB1 in cells
Catalog #: A1535

In stock

$235.00

Product Details

Cat # +Size A1535-50
Size 50 µg
Antibody Target HMGB1
Alternate Name HMGB1,HMG1
Host Mouse
Antibody Type Monoclonal
Isotype IgG2b Kappa
Immunogen A partial length recombinant HMGB1 protein (amino acids 1- 200) was used as the immunogen
Accession # P09429
Gene ID 3146
Appearance Colorless Liquid
Formulation 0.5mg/ml in Supplied in PBS containing 0.05% BSA and 0.05% Sodium azide.
Purification Protein G Chromatography
Species Reactivity Human
Application WB
Application & Usage WB: 2-4 mg/ml
Handling The antibody solution should be gently mixed before use
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HMGB1 (High-mobility group protein B1) is a 25 kDa non-histone chromatin protein, secreted by immune cells through leaderless secretory pathway. HMGB1 supports transcription and also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 has the ability to bend DNA in order to facilitate binding of other proteins to the DNA. HMGB1 has one important role in V(D)J recombination where act as a cofactor of the RAG complex. HMGB1 stimulates a plethora of cellular responses like inflammation, attracting inflammatory cells, recruiting stem cells and promoting their proliferation. HMGB1 is highly expressed in human kidney, tonsils, adipose tissue, adrenal cortex and amniotic fluid.


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