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Anti-HMG CoA Reductase Antibody

Polyclonal antibody to detect HMG CoA Reductase
Catalog #: A1304

In stock

SKU-Size Size Price Qty
A1304-30T 30 µg
$89.00
A1304-100 100 µg
$265.00

Product Details

Antibody Target HMGCR
Alternate Name 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen GST Tagged recombinant human HMG-CoA Reductase Catalytic Domain (aa 426–888)
Accession # P04035
Gene ID 3156
Appearance Colorless liquid
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
Purification Affinity purified
Species Reactivity Human
Application WB
Positive Control WB: Rat kidney lysate, HeLa, HepGe cell lysate, HMG CoA human recombinant
Application & Usage WB: 1-4 µg
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.


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