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Anti-HER2 (Trastuzumab), humanized Antibody

Monoclonal human IgG1 antibody against human HER2
Catalog #: A1046
$415.00

Product Details

Cat # +Size A1046-100
Size 100 µg
Antibody Target HER2
Alternate Name Herceptin
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG1
Immunogen Recombinant human epidermal growth factor receptor 2 (HER2)
Accession # P04626
Gene ID 2064
Appearance Colourless liquid
Formulation 100 ug of antibody in Phosphate buffered saline, pH 7.4.
Purification IgG purified from CHO culture supernatant by protein A chromatography
Species Reactivity Human
Application Neutralization, ELISA
Application & Usage Neutralization : 1-20 μg/ml; ELISA: 2μg/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C. Once thawed, store at 2-8℃
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Trastuzumab is a recombinant humanized monoclonal immunoglobulin G1 kappa antibody that binds with high affinity and specificity to the extracellular domain of the HER2 receptor. A growth factor receptor gene, human epidermal growth factor receptor (HER2), is amplified in 25 to 30 % of breast cancers and in these cases the encoded protein is present in abnormally high levels in the malignant cells. Trastuzumab is used to treat adjuvant and metastatic breast cancer as well as metastatic gastric cancer.


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Gerald Klanert, A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets. Sci Rep, June 2019;  31213643.
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