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Product Details
| Cat # +Size | A1046-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | HER2 |
| Alternate Name | Herceptin |
| Host | Recombinant |
| Antibody Type | Monoclonal |
| Isotype | Human IgG1 |
| Immunogen | Recombinant human epidermal growth factor receptor 2 (HER2) |
| Accession # | P04626 |
| Gene ID | 2064 |
| Appearance | Colourless liquid |
| Formulation | 100 ug of antibody in Phosphate buffered saline, pH 7.4. |
| Purification | IgG purified from CHO culture supernatant by protein A chromatography |
| Species Reactivity | Human |
| Application | Neutralization, ELISA |
| Application & Usage | Neutralization : 1-20 μg/ml; ELISA: 2μg/ml |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C. Once thawed, store at 2-8℃ |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Trastuzumab is a recombinant humanized monoclonal immunoglobulin G1 kappa antibody that binds with high affinity and specificity to the extracellular domain of the HER2 receptor. A growth factor receptor gene, human epidermal growth factor receptor (HER2), is amplified in 25 to 30 % of breast cancers and in these cases the encoded protein is present in abnormally high levels in the malignant cells. Trastuzumab is used to treat adjuvant and metastatic breast cancer as well as metastatic gastric cancer.
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Gerald Klanert, A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets. Sci Rep, June 2019; 31213643.
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