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Product Details
| Cat # +Size | A1046-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | HER2 |
| Alternate Name | Neu, Ngl, Erbb2, Tkr1, Cd340, Her-2, Mln 19, HER-2/neu |
| Host | Recombinant |
| Antibody Type | Monoclonal |
| Isotype | Human IgG1 |
| Immunogen | Recombinant human epidermal growth factor receptor 2 (HER2) |
| Accession # | P04626 |
| Gene ID | 2064 |
| Appearance | Colourless liquid |
| Formulation | 100 ug of antibody in Phosphate buffered saline, pH 7.4. |
| Purification | IgG purified from CHO culture supernatant by protein A chromatography |
| Species Reactivity | Human |
| Application | Neutralization, ELISA |
| Application & Usage | Neutralization : 1-20 μg/ml; ELISA: 2μg/ml |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C. Once thawed, store at 2-8℃ |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The research-grade biosimilar antibody is a recombinant
humanized monoclonal immunoglobulin G1 kappa antibody that
binds with high affinity and specificity to the extracellular domain of
the HER2 receptor. A growth factor receptor gene, human
epidermal growth factor receptor (HER2), is amplified in 25 to 30 %
of breast cancers and in these cases the encoded protein is
present in abnormally high levels in the malignant cells.
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Gerald Klanert, A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets. Sci Rep, June 2019; 31213643.
Lisa Nika. A HER2-Displaying Virus-Like Particle Vaccine Protects from Challenge with Mammary Carcinoma Cells in a Mouse Model. Vaccines (Basel) May-19. 31137559.
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