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Anti-HER2, Humanized Antibody (Pz4)

Biosimilar to Pertuzumab, monoclonal antibody that targets HER2
Catalog #: A2111
$455.00

Product Details

Cat # +Size A2111-100
Size 100 μg
Antibody Target HER2
Alternate Name HER2, HER-2, HER 2, Neu, Ngl, Erbb2, Tkr1, Cd340, Mln 19, HER-2/neu
Host CHO cells
Antibody Type Monoclonal
Isotype Human IgG1
Immunogen Human HER2
Accession # DB06366
Appearance Colorless liquid
Formulation In PBS buffer, pH 7.2
Application Growth inhibition assay, Cell cytotoxicity assay, In vivo studies
Application & Usage Growth inhibition assay, Cell Cytotoxicity assay, In vivo studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This biosimilar is a humanized monoclonal antibody that is produced by recombinant DNA technology in CHO cells and targets the extracellular domain of human epidermal growth factor receptor 2 (HER2). HER2 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. HER2 does not have a ligand binding domain so cannot bind growth factors. However, HER2 can bind tightly to other ligand-bound EGFR family members to form a heterodimer to elicit downstream signaling pathways. Amplification and/or overexpression of HER2 have been reported in numerous cancers such as breast and ovarian tumors.


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