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Anti-HER2/ErbB2 Antibody

Rabbit polyclonal antibody to detect HER2 expression in human, mouse, rat and dog samples
Catalog #: A2212
$325.00

Product Details

Cat # +Size A2212-100
Size 100 μl
Antibody Target HER2/ErbB2
Alternate Name HER2, MLN19, NEU, NGL, TKR1, HER-2, HER-2/neu, p185erbB2, CD340, EC 2.7.10.1, MLN 19, C-Erb B2/Neu Protein, CD340 Antigen, HER-2/Neu, Herstatin, EC 2.7.10, ERBB2, MLN19, TKR
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the center region of human HER2
Accession # P04626
Gene ID 2064
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse, Dog, Rat
Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting
Application & Usage WB (1:500 – 1:1000), IHC (1:100 – 1:200), IF (1:100 – 1:500)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand-binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.


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