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Anti-HDAC6 Monoclonal Antibody (D1 domain-specific)

Mouse monoclonal antibody to detect HDAC6 (D1 Domain) in human samples
Catalog #: A1485

In stock

$295.00

Product Details

Cat # +Size A1485-100
Size 100 µg
Antibody Target HDAC6
Alternate Name KIAA0901, JM21, HD6, HDAC6-D1
Host Mouse
Antibody Type Monoclonal
Isotype IgG
Immunogen Human Histone deacetylase 6 (HDAC6; sequence NP_006035.2, UniProtKB - Q9UBN7)
Accession # Q9UBN7
Gene ID 10013
Appearance Colorless Liquid
Formulation 1 mg/ml in PBS, pH 7.4, 0.02% sodium azide
Purification Affinity purified from hybridoma culture supernatant (Protein A)
Species Reactivity Human
Application ELISA, IC/IF
Positive Control HEK293T cells
Application & Usage ELISA: 1 – 10µg/ml; Immunocytochemistry/Immunofluorescence: 10 – 50 µg/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain (a.a. 281-291) of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including α-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis


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