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Product Details
| Size | 100 µl |
|---|---|
| Antibody Target | H4R3me2(asym) |
| Alternate Name | FO108; H4; H4/n; H4F2; H4FN; HIST2H4; Histone H4; HIST1H4A; HIST2H4A |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic methylated peptide targeting residues around Arginine 3 of human histone H4 |
| Accession # | P62805 |
| Gene ID | 8370 |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Purification | Affinity purified |
| Species Reactivity | Mouse, Rat, Human |
| Application | Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting |
| Application & Usage | WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack poly A tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
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