Product Details
| Antibody Target | Human histone H3, acetylated at lysine 18 |
|---|---|
| Alternate Name | H3 clustered histone 1; histone cluster 1 H3 Family Member A; Histone Cluster 1, H3a; Histone 1, H3a; Histone H3.1; Histone H3/A; HIST1H3A |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | KLH-conjugated synthetic peptide surrounding N-terminal region of human histone H3 acetylated at lysine 18 |
| Accession # | P68431 |
| Gene ID | 8350 |
| Formulation | Liquid in 0.42% potassium phosphate, 0.87% sodium chloride, pH 7.3, with 30% glycerol and 0.01% sodium azide |
| Purification | Immunogen affinity chromatography |
| Species Reactivity | Mouse, Rat, Human |
| Application | Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called “histone code.” Acetylation of histone H3 is associated with active gene transcription, and acetylation of lysine 18 on histone H3 is associated with cancer prognosis.
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