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Anti-H3K18ac Polyclonal Antibody

Polyclonal antibody that recognizes histone H3 acetylated at lysine 18, a putative tumor biomarker
Catalog #: A2359
SKU-Size Size Price Qty
A2359-50 50 µl
$195.00
A2359-100 100 µl
$325.00
More Sizes Get Quote

Product Details

Antibody Target Human histone H3, acetylated at lysine 18
Alternate Name H3 clustered histone 1; histone cluster 1 H3 Family Member A; Histone Cluster 1, H3a; Histone 1, H3a; Histone H3.1; Histone H3/A; HIST1H3A
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide surrounding N-terminal region of human histone H3 acetylated at lysine 18
Accession # P68431
Gene ID 8350
Formulation Liquid in 0.42% potassium phosphate, 0.87% sodium chloride, pH 7.3, with 30% glycerol and 0.01% sodium azide
Purification Immunogen affinity chromatography
Species Reactivity Mouse, Rat, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called “histone code.” Acetylation of histone H3 is associated with active gene transcription, and acetylation of lysine 18 on histone H3 is associated with cancer prognosis.


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