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Anti-GD2 (Naxitamab), Humanized Antibody

The biosimilar is a humanized monoclonal antibody that targets ganglioside GD2
Catalog #: A2273
$465.00

Product Details

Cat # +Size A2273-100
Size 100 μg
Antibody Target GD2 Ganglioside
Alternate Name GD2 Ganglioside, GD2, CAS 65988-71-8
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human GD2
Accession # DB15965
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant humanized IgG1 monoclonal antibody that targets ganglioside GD2. GD2 is a disialoganglioside that is expressed in neuroblastomas, melanomas, bone and soft tissue sarcomas, brain tumors, and small cell lung cancer. Although its function is not clearly understood, it may be playing an essential role in attaching tumor cells to extracellular matrix proteins. Due to its tumor-specific expression, GD2 serves as a suitable target for tumor-specific antibody therapy. The antibody binds to GD2 and causes cell death via complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). The original monoclonal antibody is FDA approved to treat adult and pediatric patients suffering from relapsed/refractory neuroblastoma.


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